Advanced paternal age is linked to which of the following inherited conditions?

Advanced paternal age is associated with an increased risk of certain genetic mutations due to the accumulation of DNA abnormalities over time in sperm. Achondroplasia, a common form of skeletal dysplasia, is one of the conditions linked to advanced paternal age. This is primarily because the majority of cases of achondroplasia arise from spontaneous mutations in the FGFR3 gene, which can occur more frequently in the sperm of older men.

As men age, the likelihood of new mutations in their sperm increases, leading to a higher risk of conditions such as achondroplasia when conception occurs. This correlation highlights the importance of paternal age in genetic counseling and family planning, especially for couples considering parenthood when the father is older. While the other conditions mentioned have their own risk factors and genetic pathways, they do not have as clear a link to advanced paternal age as achondroplasia does.