During pregnancy, a change to which immune response is observed?

During pregnancy, a notable change occurs in humoral immunity. This involves the modulation of antibody production and the overall balance of immune responses to protect both the mother and the developing fetus.

During pregnancy, there is an increase in the levels of certain antibodies, particularly immunoglobulin G (IgG). This elevation supports maternal and fetal health as IgG can cross the placenta, providing the fetus with passive immunity against infections. Additionally, a shift in the immune response occurs, favoring a more tolerant immune environment to prevent the maternal immune system from rejecting the fetus, which is genetically distinct from the mother.

Humoral immunity is essential because it helps in the production of antibodies that neutralize pathogens and provide defense. The changes observed during pregnancy are critical in ensuring that the immune response does not harm the fetus while still maintaining the ability to protect the mother from infections.

In contrast, while cell-mediated immunity may also undergo adjustments during pregnancy, such as a dampened response to prevent fetal rejection, the most recognized and significant adaptation involves humoral immunity. This difference highlights the complex interplay of immune responses needed to achieve a successful pregnancy.