How long can Etretinate remain in the system after administration?

Etretinate, a retinoid previously used for the treatment of severe psoriasis, has a long half-life due to its lipophilicity and tendency to accumulate in adipose tissue. Once administered, it can remain in the body for an extended period, primarily because it is slowly released from fat stores. The available data indicate that etretinate can persist in the system for a duration ranging from 2 to 3 years. Given this prolonged retention, patients who have been treated with etretinate may still carry the drug's potential effects long after its discontinuation, which is particularly important in considerations for pregnancy. Understanding this characteristic of etretinate helps healthcare providers manage risks effectively for women of childbearing age.