In Antiphospholipid Antibody Syndrome, what is the most common thrombotic event?

In Antiphospholipid Antibody Syndrome (APS), the most common thrombotic event is deep vein thrombosis (DVT). This condition is characterized by the presence of antiphospholipid antibodies that lead to an increased risk of venous and arterial thromboembolism. DVT tends to occur more frequently in patients with APS because the condition primarily affects venous circulation.

The pathophysiology involves increased activation of coagulation pathways, leading to a hypercoagulable state, which often manifests as a thrombus formation in deep veins, particularly in the legs. While other thrombotic events like ischemic stroke, myocardial infarction, and pulmonary embolism can still occur, they are less common than DVT in patients with APS. Understanding the prevalence of these events is crucial for clinicians in order to provide effective management and prevention strategies for patients at higher risk.