In which condition would you most likely find clenched hands and microcephaly?

The presence of clenched hands and microcephaly is most closely associated with Smith-Lemli-Opitz Syndrome. This condition is a genetic disorder caused by a defect in cholesterol synthesis, which leads to a variety of developmental and physical abnormalities. Individuals with this syndrome often exhibit features such as microcephaly (smaller than average head size), facial dysmorphisms, and limb malformations, including clenched hands, which is a significant clinical indicator.

In contrast, while conditions like Meckel-Gruber Syndrome and others have their own characteristic features, they do not typically present with both clenched hands and microcephaly as a defining combination. Meckel-Gruber Syndrome is associated more with cystic renal dysplasia and other organ malformations, Pierre Robin Syndrome primarily involves facial structural abnormalities like a cleft palate and underdeveloped jaw, while Treacher-Collins Syndrome features craniofacial deformities but not specifically clenched hands or microcephaly. This makes Smith-Lemli-Opitz Syndrome the most relevant condition in this context.