What cell type is primarily involved in Non-Hodgkin's Lymphoma?

Non-Hodgkin's Lymphoma (NHL) is a heterogeneous group of lymphoproliferative disorders, and its classification includes lymphomas that originate primarily from lymphoid tissues, specifically B cells and T cells.

B cells play a central role in the majority of NHL cases, accounting for approximately 85% of all non-Hodgkin lymphomas. These lymphomas can be derived from various stages of B cell development, reflecting the diversity of the immune system and how these cells can respond to various stimuli.

T cells are less commonly involved in NHL but still represent a significant portion of lymphomas, particularly in cases such as peripheral T-cell lymphoma and anaplastic large cell lymphoma. Therefore, T cell involvement in NHL is important and contributes to the variability seen in the disease's presentation and behavior.

Natural Killer (NK) cells typically do not give rise to Non-Hodgkin's Lymphoma, although they can be involved in other lymphoproliferative disorders.

Given this information, the correct answer reflects the involvement of both B and T cells in the pathology of Non-Hodgkin's Lymphoma, highlighting the complex nature of this group of diseases.