What condition has a frequent association with single umbilical artery?

A single umbilical artery (SUA) is a congenital anomaly where only one artery is present instead of the normal two umbilical arteries. This condition is commonly associated with various anatomic and genetic abnormalities. Trisomy 18, also known as Edward's syndrome, is characterized by multiple congenital defects and is the most frequently associated chromosomal abnormality with SUA.

In cases of Trisomy 18, the presence of SUA is observed with increased frequency due to the underlying developmental anomalies and disturbances associated with the trisomy. The other conditions listed, while they may also have some associations with SUA, do not show the same level of significance or frequency as Trisomy 18. Thus, the link between SUA and Trisomy 18 is a well-documented clinical finding, making this answer the most accurate choice regarding the association.