What demographic is most commonly affected by May-Thurner Syndrome?

May-Thurner Syndrome is a condition characterized by the compression of the left common iliac vein by the overlying right common iliac artery, leading to significant venous stasis and an increased risk of deep vein thrombosis (DVT) in the affected leg. Epidemiological studies primarily identify women between the ages of 20 and 40 as the demographic most frequently impacted by this condition. Factors contributing to this prevalence include hormonal influences and other anatomic variations that may predispose younger women to venous complications, particularly during periods of increased estrogen, such as pregnancy or the use of hormonal contraceptives.

Even though other demographics appear in the options, such as men or younger children, they do not reflect the higher incidence of May-Thurner Syndrome seen in young to middle-aged women. Thus, the prominence of this age group in clinical findings underscores the importance of considering it in differential diagnoses when assessing venous issues in that demographic.