What enzyme is associated with preterm labor?

Phospholipase A2 is an enzyme that plays a significant role in the processes leading to preterm labor. It is involved in the hydrolysis of phospholipids, which results in the release of arachidonic acid. Arachidonic acid subsequently serves as a precursor for various inflammatory mediators, including prostaglandins and leukotrienes, which are known to induce uterine contractions and cervical ripening. The inflammatory process initiated by these mediators can contribute to the onset of labor, particularly preterm labor.

In the context of preterm labor, an increase in the levels of phospholipase A2 and its products can be observed. This suggests that it plays a critical role in the signaling pathways that lead to labor initiation. Thus, the association of phospholipase A2 with preterm labor highlights its potential as a target for research into prevention and management strategies in obstetrics.