What histopathological finding is characteristic of chorioamnionitis?

The characteristic histopathological finding of chorioamnionitis is the presence of neutrophils and mononuclear cells in the chorion. Chorioamnionitis is an intra-amniotic infection that leads to an inflammatory response, primarily characterized by the infiltration of neutrophils and other immune cells into the membranes of the placenta, particularly the chorion. This inflammatory response can be further assessed by examining tissue samples under a microscope to identify these cellular infiltrates.

Neutrophils are typically one of the first responders to infection, indicating an acute inflammatory response, while mononuclear cells are associated with both acute and chronic inflammation. Their presence in the chorion suggests that the infection has triggered an immune response that is detectable through histological examination. This finding is essential in diagnosing chorioamnionitis and assessing the severity of the condition, as it can lead to various maternal and neonatal complications.

The other choices do not represent the specific histopathological features associated with chorioamnionitis. For instance, a large, pale placenta may indicate various conditions, including fetal compromise or other placental pathologies, but is not specific to chorioamnionitis. Increased fetal red blood cells in vessels may suggest conditions like hemorrhage or fetal