What increases the platelet count by 1000-5000 units?

The increase in platelet count by 1000-5000 units is primarily associated with the transfusion of platelets. Platelet transfusions are specifically designed to elevate the platelet count in patients who are experiencing thrombocytopenia due to various causes, such as bone marrow disorders, chemotherapy, or certain diseases that affect platelet production.

When platelet concentrates are transfused, they can provide a significant boost to the circulating platelet mass, leading to the specified increase in count. Typically, a single adult-sized platelet transfusion (which is derived from a pool of random donor platelets) is expected to raise the platelet count by approximately 30,000 to 60,000 per unit, depending on the individual's response and underlying condition. In clinical practice, this means that the transfusion of platelets is an effective and targeted approach in managing patients with low platelet counts.

In contrast, whole blood and packed red blood cells primarily affect hemoglobin levels and may not significantly influence platelet counts. Fresh frozen plasma is mainly used to correct coagulopathy and replace clotting factors rather than to increase platelet levels. Therefore, the mechanism and purpose behind platelet transfusion directly align with the increase in platelet count observed in the given scenario.