What is a common contraindication for Nevirapine, a non-nucleoside reverse transcriptase inhibitor?

Nevirapine is a medication used in the treatment of HIV, particularly as part of antiretroviral therapy. One of the most significant contraindications for its use is severe liver failure. This is because Nevirapine is metabolized primarily in the liver. In patients with compromised liver function, the drug can accumulate, leading to an increased risk of toxicity. Furthermore, Nevirapine itself has been associated with hepatotoxicity, meaning it can cause liver damage or exacerbate existing liver conditions.

In conditions such as severe liver failure, the risk of adverse effects increases significantly, which can lead to serious health consequences for the patient. Therefore, in individuals with significant hepatic impairment, Nevirapine is contraindicated to ensure patient safety and minimize the risk of liver-related complications during treatment.