What is a significant increase in fibrinogen associated with fresh frozen plasma?

The significant increase in fibrinogen associated with fresh frozen plasma (FFP) is clinically relevant, as fibrinogen is an essential component in coagulation and wound healing. Fresh frozen plasma is often used to correct coagulopathy and restore clotting factors in patients.

When FFP is administered, it can lead to an increase in fibrinogen levels, typically in the range of 10-15 mg/dL. This increase is significant because it enhances hemostatic capacity, particularly in patients with low fibrinogen levels due to conditions such as disseminated intravascular coagulation (DIC), liver disease, or massive hemorrhage.

Understanding the expected increase in fibrinogen after the transfusion of FFP helps clinicians predict and monitor the therapeutic effects of the intervention, ensuring proper management of coagulopathy and effective patient care. Therefore, the choice indicating a 10-15 mg/dL increase reflects the recognized clinical impact and therapeutic goal in the use of fresh frozen plasma.