What is the primary cell type associated with Reed-Sternberg cells in Hodgkin's Lymphoma?

Reed-Sternberg cells are a distinctive feature of Hodgkin's Lymphoma and are derived from B cells, which are a type of white blood cell involved in the immune response. These cells exhibit abnormal characteristics and play a key role in the pathophysiology of Hodgkin's Lymphoma.

The presence of Reed-Sternberg cells, which are typically large, binucleated cells, is crucial for the diagnosis of this lymphoma type. Their origins from B cells highlight the importance of this cell lineage in the disease. In the context of Hodgkin's Lymphoma, the presence of these cells is often associated with a mixed inflammatory background that includes various immune cells, but their identity as neoplastic B cells is what primarily defines the disease.

Understanding this connection is pivotal when studying the pathology of Hodgkin's Lymphoma, as it underscores how the transformation of normal B cells leads to the development of malignancy and the clinical features associated with the disease.