What is the primary mechanism behind May-Thurner Syndrome?

May-Thurner Syndrome primarily results from the compression of the left common iliac vein by the right common iliac artery. This anatomical relationship leads to an increased risk of venous thromboembolism in the left leg due to the resulting stenosis and turbulence in blood flow. The right iliac artery, typically positioned in a more anterior location than the left common iliac vein, exerts pressure on the vein, which can potentially lead to clot formation.

Understanding this mechanism is crucial for recognizing May-Thurner Syndrome in clinical practice. Patients may present with symptoms related to deep vein thrombosis or chronic venous insufficiency in the left leg, and an awareness of this syndrome can guide appropriate imaging and treatment approaches. The primary issue lies in the abnormal compression created by the vascular structures, highlighting the importance of considering anatomical variations in venous disorders.