What is the risk of neural tube defects (NTD) associated with valproic acid?

Valproic acid is an antiepileptic medication that has been associated with a significant risk of neural tube defects (NTDs) when used during pregnancy, particularly in the first trimester. Research indicates that the incidence of NTDs in pregnancies exposed to valproic acid can range significantly higher than the typical background rates found in the general population.

The correct response for the risk of NTDs associated with valproic acid is approximately 10-15%. This higher percentage reflects findings from various studies, which have consistently identified valproic acid as a teratogen associated with a notable risk of serious embryonic malformations, including NTDs such as spina bifida.

To summarize, the understanding of teratogenic risks associated with valproic acid underscores the importance of proper counseling and management of women of childbearing age who require antiepileptic therapy, making it critical for healthcare providers to be aware of such risks during preconception and prenatal care.