What is the risk percentage of congenital heart block in infants from mothers with SSA/SSB antibodies?

Congenital heart block is a rare condition that can occur in infants of mothers who have antibodies to Sjögren's syndrome, specifically SSA (Ro) and SSB (La) antibodies. Studies indicate that approximately 2-5% of infants born to mothers with these antibodies may develop congenital heart block.

Focusing on the correct answer, which is 3%, this value reflects the midrange risk often cited in medical literature regarding the incidence of congenital heart block in these cases. The risk can vary depending on specific maternal and fetal factors, but 3% serves as a useful benchmark for understanding the likelihood of this complication occurring in newborns when the mother has SSA/SSB antibodies.

While there may be higher and lower estimates within the 2-5% range, the 3% figure appropriately captures the representative risk and provides a solid clinical guideline for practitioners evaluating the risk in similar cases.