What percentage of patients with Sjogren's Syndrome are associated with SSA/SSB antibodies?

The percentage of patients with Sjogren's Syndrome who are associated with SSA (anti-Ro) and SSB (anti-La) antibodies is indeed around 90%. These antibodies are significant biomarkers for the diagnosis of Sjogren's Syndrome, as they are found in a large proportion of individuals with this condition.

Having a high prevalence of these antibodies among patients with Sjogren's Syndrome underscores their role in the pathophysiology and diagnosis of the disorder. The presence of SSA and SSB antibodies is common enough that they are often used in clinical practice to help confirm a diagnosis when patients present with the characteristic symptoms of dry eyes and dry mouth, along with other systemic manifestations.

In terms of variation, while SSA and SSB antibodies are present in a considerable percentage of patients, the specific incidence can depend on the population studied. However, with the established range of 90%, it provides a strong indication of their association with Sjogren's Syndrome. This figure emphasizes the importance of serological testing in evaluating patients suspected of having this autoimmune condition, all while recognizing the possible presence of these antibodies in other overlapping autoimmune diseases.