Where is PGF2α primarily synthesized?

PGF2α, or Prostaglandin F2 alpha, is primarily synthesized in the decidua, which is the modified mucosal lining of the uterus during pregnancy. The decidua plays a crucial role in the implantation of the embryo and the maintenance of pregnancy. Prostaglandins like PGF2α are involved in various physiological processes, including regulating uterine contractions during labor and modulating the inflammatory response in the uterus.

While prostaglandins can also be produced in other tissues, such as the endometrium, ovary, and even the placenta to a certain extent, the decidua is the primary site for PGF2α synthesis in the context of pregnancy. This synthesis is important because PGF2α is involved in processes such as cervical ripening and the onset of labor, underlining its significance during both pregnancy maintenance and parturition.