Which action is NOT associated with Metformin?

The action that is not associated with Metformin is the decrease in intestinal absorption of glucose. Metformin primarily works through several mechanisms, primarily focusing on reducing hepatic glucose production and enhancing insulin sensitivity rather than directly altering glucose absorption in the intestines.

Metformin decreases hepatic gluconeogenesis, which is its primary action. This means it effectively lowers the amount of glucose produced by the liver, leading to an overall reduction in blood sugar levels. Additionally, it mildly increases peripheral glucose utilization, which means it helps tissues, especially muscles, respond better to insulin and use glucose more effectively.

While AMP-activated protein kinase (AMPK) activation plays a role in Metformin's mechanisms, it does not act independently on AMPK as its mode of action involves multiple pathways. Therefore, the option regarding the decrease in intestinal absorption is the correct choice as it does not reflect any known activity of Metformin.