Which class of anti-HIV medication is associated with weight gain and increased creatinine kinase?

The correct answer is integrase inhibitors. This class of anti-HIV medications has been associated with weight gain in some patients. The specific mechanisms are not entirely understood, but it appears that these medications may influence metabolic pathways that are linked to weight management and fat distribution.

Additionally, some integrase inhibitors can lead to elevated muscle enzymes, including creatinine kinase. This elevation is particularly important as it may indicate muscle damage or myopathy, which could be a concern for clinicians monitoring their patients undergoing treatment.

Understanding the different classes of anti-HIV medications is crucial, as each class has its own side effect profile and implications for patient management, especially regarding metabolic health and muscle function.