Which condition is associated with low estriol on a Quad Screen?

Low estriol levels on a Quad Screen are particularly associated with Placental sulfatase deficiency. This condition leads to the impairment of the conversion of dehydroepiandrosterone sulfate (DHEAS) to estriol, resulting in reduced estriol production during pregnancy. As estriol is one of the markers measured in the Quad Screen, low levels can indicate a potential issue with the placental function, as seen in this deficiency.

In contrast, conditions such as neural tube defects, obesity, and Meckel-Gruber syndrome do not specifically correlate with low estriol levels on a Quad Screen. Neural tube defects are usually identified by elevated alpha-fetoprotein (AFP) levels rather than low estriol. Obesity can affect the levels of various markers in the Quad Screen but does not have a direct association with low estriol. Meckel-Gruber syndrome is a rare congenital disorder that is not typically reflected in estriol levels.