Which laboratory finding is least likely to be seen during an SLE flare in pregnancy?

In the context of Systemic Lupus Erythematosus (SLE) during pregnancy, understanding the implications of various laboratory findings is essential.

High IgG levels can be relatively common and might not specifically indicate an SLE flare. This is because, during pregnancy, there is a natural increase in serum IgG levels as the body adapts to support both the mother's and the developing fetus's immune needs. While these elevated levels could reflect a variety of immune activities, they do not directly correlate with SLE disease activity or a flare.

On the other hand, leukopenia is a known manifestation of SLE exacerbations and can occur due to the disease itself or related to medications. Low complement levels are also a signature feature of SLE flares, as the complement system is often activated in response to the presence of autoantibodies. Additionally, increasing anti-dsDNA levels are very specific to SLE flares and correlate with disease activity, making them a critical marker in both pregnant and non-pregnant patients.

Therefore, considering the context of SLE flare during pregnancy, elevated IgG levels do not signify an increase in disease activity, differentiating them from other laboratory findings that are more closely associated with an S