Which medication is contraindicated during pregnancy for migraine treatment?

Ergotamine is contraindicated during pregnancy for the treatment of migraines due to its potential to cause uterine contractions and potentially lead to adverse pregnancy outcomes, such as miscarriage or preterm labor. This medication acts as a potent vasoconstrictor and can stimulate the uterus, which poses significant risks to fetal health and development.

In contrast, sumatriptan, while used with caution, may be prescribed in certain cases because its effects on pregnancy are considered less harmful compared to ergotamine. Aspirin and ibuprofen, particularly during the first and second trimesters, can be used with caution, especially for conditions like preeclampsia, but they should be avoided as the pregnancy approaches term due to the risk of bleeding or other complications. However, the primary concern with ergotamine is its direct impact on uterine activity, making it the most concerning option among those listed for migraine treatment during pregnancy.