Which of the following conditions is characterized by a beaded appearance of ribs?

The condition characterized by a beaded appearance of the ribs is Osteogenesis Imperfecta. This disorder is a genetic condition that affects the production of collagen, a critical protein for bone strength and integrity. As a result, individuals with Osteogenesis Imperfecta often experience brittle bones that fracture easily.

The beaded appearance of ribs in this condition arises due to the irregularities in bone mineralization and structure. The ribs may show abnormal shapes and sizes, leading to this distinctive appearance, which can be seen on imaging studies like X-rays.

Additionally, in Osteogenesis Imperfecta, patients may also present with other skeletal deformities, blue sclera, dental issues, and hearing loss, further showcasing the systemic implications of the underlying collagen deficiency. This unique association with rib appearance helps in the clinical diagnosis of the condition among the options provided.