Which of the following drugs is associated with reversible ototoxicity in the fetus?

Aspirin has been associated with reversible ototoxicity in the fetus due to its impact on fetal development. Ototoxicity refers to drug-induced damage to the hearing structures in the ear, which can lead to hearing loss. Aspirin, particularly when taken during the third trimester of pregnancy, is known to have various effects on the fetus, one of which includes affecting the auditory system.

The mechanism behind this is likely related to aspirin's actions on prostaglandins, which play a crucial role in the development of the auditory system. When aspirin crosses the placental barrier, it can lead to side effects that the fetus may experience, including potential changes in auditory function. This effect is particularly significant because it can lead to temporary hearing issues, which are generally reversible upon discontinuation of the drug and correction of any underlying issues.

In contrast, amoxicillin and paracetamol do not have a well-established association with ototoxicity, either in fetuses or in general. While ibuprofen can affect fetal health, particularly concerning cardiovascular implications (like premature closure of the ductus arteriosus), it is not classically linked with ototoxicity. Therefore, the connection between aspirin and reversible ototoxicity in fetuses distinguishes it as the