Which of the following is a key feature of Pemphigoid gestationis?

Pemphigoid gestationis is characterized by the presence of pruritic blisters that primarily appear around the umbilical region, which is why this response is the correct answer. This autoimmune condition typically presents in the second or third trimester of pregnancy and may also involve widespread eruptions, but the hallmark feature is the vesicular lesions that start in and around the umbilical area.

The disease is a type of autoimmune blistering disorder and the distinctive nature of the vesicular lesions is crucial for diagnosis. The fact that these lesions can extend beyond the umbilicus to the abdomen and other areas can sometimes cause confusion, but the initial presentation is a key aspect that distinguishes it from other dermatological conditions.

The other responses lack specificity or alignment with the typical manifestations of pemphigoid gestationis. An itchy rash can be seen in various conditions, but the specific vesicular rash is critical for pemphigoid. Similarly, while systemic symptoms like fever might occur in other dermatological conditions, they are not a feature of pemphigoid gestationis, which typically does not present with systemic symptoms like fever and body aches. Dermatitis of the extremities does not reflect the central characteristic of this condition, which is primarily