Which of the following is the most common inherited coagulopathy?

Von Willebrand Disease is indeed the most common inherited coagulopathy. This condition is characterized by a deficiency or dysfunction of von Willebrand factor (vWF), which plays a crucial role in platelet adhesion and aggregation, fundamental processes in normal blood clotting.

The various types of von Willebrand Disease can lead to a range of bleeding symptoms, such as mucosal bleeding, easy bruising, and heavy menstrual periods. The prevalence of von Willebrand Disease in the general population makes it the most common inherited disorder when compared to other coagulopathies.

In contrast, other conditions listed, while also significant, are less prevalent. Factor V Leiden is a genetic mutation associated with an increased risk of thrombosis rather than a coagulopathy that leads to bleeding. Hemophilia A is an X-linked recessive disorder that predominantly affects males and is characterized by factor VIII deficiency, making it less common than von Willebrand Disease. Antiphospholipid Syndrome is an acquired condition associated with thrombosis and pregnancy complications, rather than being an inherited coagulopathy.

Overall, von Willebrand Disease stands out as the most prevalent inherited bleeding disorder, leading to its designation as the correct answer.