Which statement is true regarding protease inhibitors?

Protease inhibitors are a class of antiviral drugs commonly used in the treatment of viral infections such as HIV and hepatitis C. The statement regarding their association with gastrointestinal (GI) distress is accurate. Many patients taking protease inhibitors often report side effects like nausea, diarrhea, and abdominal discomfort, which are related to their pharmacological effects and impact on the gastrointestinal system.

In terms of their use, while they are indeed effective as part of a combination therapy in treating various viral infections, they are not restricted solely to first-line treatment and can be integrated into treatment plans at different stages depending on the individual's specific circumstances and treatment history. Protease inhibitors have also shown effectiveness when treating co-infections, including cases involving hepatitis, which contradicts the notion that they are ineffective in such patients.

Understanding the side effects of protease inhibitors, particularly their gastrointestinal effects, is important for managing patient care and improving adherence to medication regimens. This insight is crucial for both healthcare providers and patients in making informed decisions about antiviral therapies.