Which syndrome is associated with a strawberry-shaped skull?

The strawberry-shaped skull is primarily associated with Trisomy 18, also known as Edwards Syndrome. This distinctive skull shape is characterized by a prominent forehead and a narrowed or "pointed" appearance at the back of the head, resembling a strawberry.

Trisomy 18 is a chromosomal disorder caused by the presence of an extra chromosome 18, leading to a variety of developmental and physical abnormalities. Alongside the cranial features, affected individuals often present with other clinical signs such as clenched fists, overlapping fingers, and various heart defects.

Understanding the specific characteristic features of each syndrome helps clarify why Trisomy 18 stands out in this context. Other syndromes listed do not typically feature the distinctive skull shape associated with Trisomy 18.